Thiotepa stability

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August undefined, 2024

Weband Stability Chart in Appendix. Additional information: Do not use reconstituted solutions that are opaque or contain a precipitate after filtration thorough a 0.22 micron filter. 2. … WebSep 17, 2024 · A composition according to the present invention can very effectively prevent, ameliorate, or treat gastric cancer, specifically intractable gastric cancer, by screening a subject with suitable generic characteristics for a drug capable of suppressing caveolin-1-mediated endocytosis, and administering the drug into the screened subject.

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WebNov 1, 1997 · The stability of thiotepa in a new formulation of the drug was studied. Vials of Thioplex (Immunex), a relatively new lyophilized formulation of thiotepa, were … WebJan 1, 2024 · "Thiotepa" published on Jan 2024 by ASHP. "Thiotepa" published on Jan 2024 by ASHP. ... Stokes TF, Sumner ED. Particulate contamination and stability of three additives in 0.9% sodium chloride injection in plastic and glass large-volume containers. Am J Hosp Pharm. 1975; 32:821–6. [PubMed 1146840] georgetown texas golf courses

Mechanisms and kinetics of thiotepa and tepa hydrolysis: DFT study

WebMay 10, 2000 · The stability of thioTEPA and its metabolites in urine and plasma strongly depends on the pH (Table 1), showing increased degradation at lower pH. The degradations followed pseudo-first order kinetics. Degradation rates in urine at 22°C are approximately 1.5–3 times lower than at 37°C. ThioTEPA and TEPA were far more stable in plasma than ... WebNov 15, 1997 · Thiotepa 1 and 3 mg/mL was stable for 48 hours at 8 degrees C and for 24 hours at 25 degrees C. Thiotepa 0.5 mg/mL was not stable at either temperature. Storage … WebStability: At temperatures above 2–8°C, thiotepa polymerizes and becomes inactive. The bulk drug is stable (up to two years) at 2–8°C, is unstable in acid and is sensitive to light. Aqueous solutions of 10 mg/ml are stable … christian elger neuroleadership

Thiotepa - an overview ScienceDirect Topics

Stability of thioTEPA and its metabolites, TEPA ... - PubMed

WebN,N',N"-Triethylenethiophosphoramide (thiotepa) was dissolved at 100 micrograms/ml in urine or in 0.1 M sodium acetate buffer and incubated at 37 degrees or 22 degrees. After 0, 15, 30, 60, 90, and 120 min of incubation, 0.1-ml samples were extracted into ethyl acetate and analyzed by gas-liquid chr … Web第七章抗肿瘤药.pptx,Chapter 13 Antineoplastic Agents;Classification by mechanism; 13.1 Biological alkylating agents; Bioalkylating agents are cytotoxic drugs. In vivo, it is able to form a positive charged carbon-ion or other active electrophilic groups, and then the el christian elgueaWebFeb 14, 2012 · N,N′,N″-triethylenethiophosphoramide (Thiotepa) and its oxo analogue (Tepa) as the major metabolite are trifunctional alkylating agents with a broad spectrum of antitumor activity. In vivo and vitro studies show alkylation of DNA by Thiotepa and Tepa can follow two pathways, but it remains unclear which pathway represents the precise … christian elfers nordwalde

"WebNov 3, 1993 · Purpose: This prospective randomized cooperative group study was conducted in patients with neoplastic meningitis treated with intrathecal methotrexate or thiotepa to assess response rates and survival, prognostic factors, and the toxicity of these regimens. Patients and methods: Fifty-nine adults with nonleukemic malignancies, … " - Thiotepa stability

Thiotepa stability

WebA method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by … WebAug 1, 2000 · N,N′,N′′-triethylenethiophosphoramide (thioTEPA) is a trifunctional alkylating agent with a broad spectrum of antitumour activity developed in the 1950s. The drug is now experiencing renewed interest as it appears to be one of the most effective anticancer drugs in high dose regimens. ... Stability of thioTEPA (lyophilised) in 0.9% sodium ...

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WebMay 10, 2000 · The influences of pH and temperature on the stability of thioTEPA and its metabolites were studied. An increase in degradation rate was observed with decreasing pH as measured for all studied metabolites. In urine the rate of degradation at 37 degrees C was approximately 2.5+/-1 times higher than at 22 degrees C. At 37 degrees C thioTEPA and ... WebNov 15, 1997 · The stability of thiotepa in a new formulation of the drug was studied. Vials of Thioplex (Immunex), a relatively new lyophilized formulation of thiotepa, were reconstituted with sterile water and diluted with 0.9% sodium chloride injection in polyvinyl chloride infusion bags to thiotepa concentrations of 0.5, 1, and 3 mg/mL. The solutions …

WebJan 17, 2024 · Thiotepa concentrations were determined using a stability-indicating RP-HPLC assay. In parallel, pH and osmolality were measured. Sub-visible particles were counted on day 0 and 14. WebThiotepa for Injection, USP Safety Data Sheet (SDS) July 24, 2024 SDS No.: SDS 095 SDS Version No.: 1.0 Form No.: R-SOP-009-F001 Page: 5of 9 (o) Partition Coefficient: n-octanol/water 0.53 (p) Auto-ignition Temperature Not available (q) Decomposition Temperature Not available (r) Viscosity Not available Section 10 -Stability and Reactivity

WebNov 15, 1996 · The stability of thiotepa (lyophilized) 0.5 and 5 mg/mL in 5% dextrose injection was studied. Vials of lyophilized thiotepa were reconstituted with sterile water … WebFeb 14, 2010 · A number of studies have described the effect of pH on the stability of thiotepa and tepa [9–11]. Although the authors did not determine the pK a values of these compounds explicitly, we can conclude from their studies that the value of pK a should be low. Our theoretical results obtained with the different sets of radii confirm this trend.

WebThiotepa C6H12N3PS CID 5453 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. National Institutes of Health. National Library of Medicine. National Center for Biotechnology Information. PubChem ...

WebMay 10, 2000 · The stability of thioTEPA-mercapturate was studied in urine adjusted to pH 4,5 or 6 with acetic acid or sodium hydroxide at a concentration of 20 μg/ml. Samples … christian eletronic devices filterWebAnother metabolite reported was a thiotepa-mercapturate conjugate [218, 220, 228]. Model metabolites prepared and analyzed were a thiotepa-glutathione conjugate [221, 229] and a thiotepa-hemoglobin conjugate [221]. Also studied was the effect of hydrazine sulfate on inhibiting thiotepa metabolite formation [230] and metabolite stability [231]. georgetown texas high school football scoresWebFeb 6, 2024 · Prior to intravesical administration, patients should be dehydrated for 8–12 hours. Instill 60 mL of diluted thiotepa solution by catheter into the bladder; retain solution … georgetown texas holiday eventsWebAim and objectives Due to lack of long-term stability data for newly formulated Thiotepa Riemser RTA solutions, the physicochemical in-use stability of diluted infusion solutions … georgetown texas handmade soapWebSep 6, 2024 · Thiotepa may be given by rapid intravenous administration in doses of 0.3 to 0.4 mg/kg. Doses should be given at 1 to 4 week intervals. The dosage recommended is 0.6 to 0.8 mg/kg. Administration is usually effected through the same tubing which is used to … georgetown texas historic district georgetown texas high schoolWebJan 17, 2024 · The analysis of the physicochemical stability of some Thiotepa preparations as a function of temperature and time is reported. The analysis was performed using the … christian elias top light entertainment