WebMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene … WebNov 15, 1993 · We identified from a rat brain cDNA library an isolate encoding the phosducin-like protein (PhLP), which has 41% identity and 65% amino acid homology to phosducin. PhLP cDNA is expressed in all tissues screened by RNA blot-hybridization analysis and shows marked evolutionary conservation on Southern hybridization. We have …
Pdcl3 MGI Mouse Gene Detail - MGI:1916083 - phosducin-like 3
WebG-protein function is normally regulated by the occurrence of multiple isoforms of the a, ,3, and y subunits, alterations in a-subunit abundance, and by G protein-associated proteins that modulate GTPase activity or coupling to receptor/ effector molecules (see refs. 25-28 for reviews). One such G protein-regulatory protein is phosducin, a ... WebSep 22, 2000 · The identification of phosducin and PhLP as new substrates for GRK2 further expands the cellular roles of this kinase and suggests new mechanisms for modulating GPCR signal transduction. G protein-coupled receptor kinase 2 (GRK2) is able to phosphorylate a variety of agonist-occupied G protein-coupled receptors (GPCR) and … cytiva oligonucleotide synthesis
The physiological roles of phosducin: from retinal function
WebPhosducin and phosducin-like protein are both phosphorylated by GRK2 in vitro resulting in a reduced ability of these proteins to bind G ... The activity of G protein βγ subunits is … WebPhosducin is a 33-kDa protein, a cytosolic regulator of G-protein-mediated signaling, found in the retina and also in nonretinal tissues such as liver, lung, heart, and brain. From: … WebJun 10, 2015 · A recent study suggests that phosducin-like 3 (PDCL3) associates with VEGFR-2 and inhibits its 26S-proteasomal-dependent degradation . Association of PDCL3 … cytiva packing reservoir